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Title: The Odontogenic Differentiation of Human Dental Pulp Stem Cells on Hydroxyapatite-Coated Biodegradable Nanofibrous Scaffolds
Journal: International Journal of Polymeric Materials and Polymeric Biomaterials
Author: 1. Effat Alizadeh, 1,2. Fatemeh Asghari, 1,2,3. Roya Salehi, 1,5. Soodabeh Davaran, 2. Negar Abbasi Aval, 2,5. Khosro Adibkia, 3,4. Marziyeh Agazadeh, 4. Mohammad Samiei
Year: 2016
Address: 1. School of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran, 2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 3. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 4. School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran, 5. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: This study aimed to design nanofibrous (NF) scaffolds that facilitate odontogenic and osteogenic differentiation of human dental pulp-derived mesenchymal stem cells (DPSCs) in vitro. For this purpose, hydroxyl apatite (HA)-loaded poly (L-lactic acid)/poly (ɛ-caprolactone) (PLLA:PCL 2;1) blend NFs were prepared using the electrospinning method. Alizarin red activity and cell viability were evaluated by MTT assay, and SEM revealed the proliferation properties of NF scaffolds. QRT-PCR results demonstrated that HA-loaded PLLA/PCL can lead to osteoblast/odontoblast differentiation in DPSCs through the up-regulation of related genes, thus indicating that electrospun biodegradable PCL/PLA/HA has remarkable prospects as scaffolds for bone and tooth tissue engineering.
Keywords: Tissue engineering, Dental Pulp Stem cells, Regenerative Medicine, Scaffold, Odontogenic, Differentiation, Nanofibers
Application: Scaffold, Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.1080/00914037.2016.1163564#="http://www.tandfonline.com" & "/doi/abs/10.1080/00914037.2016.1163564"#