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Title: UiO-66 metal organic framework nanoparticles loaded carboxymethyl chitosan/poly ethylene oxide/polyurethane core-shell nanofibers for controlled release of doxorubicin and folic acid
Journal: International Journal of Biological Macromolecules
Author: 1. Amirnezam Farboudi, 2. Khadijeh Mahboobnia, 3. Faraz Chogan, Mahsa Karimi, 4. Anis Askari, 5. Solmaz Banihashem, 6. Soodabeh Davaran, 7. Mohammad Irani
Year: 2020
Address: 1. Faculty of Pharmacy, Eastern Mediterranean University, North Cyprus, Turkey 2. Department of Laboratory Medicine, Faculty of Paramedical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 3. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran 4. Department of Chemical Engineering, Amirkabir University of Technology, Tehran, Iran 5. Department of Chemistry, College of Basic Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran 6. Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Iran 7. Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
Abstract: Doxorubicin (DOX) and folic acid (FA) were incorporated into the UiO-66 metal organic framework (MOF) and following were loaded into the carboxymethyl chitosan/poly ethylene oxide (PEO)/polyurethane core-shell nanofibers for controlled release of DOX and FA toward MCF-7 cells death. The synthesized nanocarriers were characterized using TEM, XRD, and SEM analysis. The drug loading efficiency and release profiles of DOX/MOF and FA/MOF from synthesized nanofibers have been investigated. The fitting of kinetic data by the pharmacokinetic models demonstrated the non-Fickian diffusion from nanofibers and Fickian diffusion from core-shell fibers. The cytotoxicity of synthesized nanofibers toward MCF-7 cancer cells was evaluated using DAPI staining, MTT assay and flow cytometry tests to investigate the simultaneous use of DOX and FA in the nanofibrous matrix for MCF-7 cells death in vitro. The maximum cell death using DOX-FA loaded-core-shell fibers produced by coaxial electrospinning method under 0.3, 0.5 and 0.8 mLh−1 shell flow rates were found to be 82 ± 0.7, 83 ± 0.5 and 87 ± 0.5% after 168, 240 and 240 h, respectively. The cytotoxicity results indicated that the co-delivery of DOX and FA into the core-shell fibers could be widely used for various cancers treatment.
Keywords: Carboxymethyl chitosan, UiO-66 metal organic framework, Core-shell nanofibers Doxorubicin, Folic acid
Application: Drug Delivery
Product Model 1: Syringe Pump
Product Model 2: High Voltage Power Supply (HV35POV)
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