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Title: Preparation of antibacterial electrospun Poly lactic-co–glycolic acid nanofibers containing Hypericum Perforatum with bedsore healing property and evaluation of its drug release performance
Journal: International Journal of Nano Dimension
Author: 1. Faegheh Pourhojat , Mahmoodreza Sohrabi , 2. Shahab Shariati, 3. Hamid Mahdavi, 4. Leila Asadpour
Year: 2018
Address: 1. Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran 2. Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran 3. Iran Polymer and Petrochemical Institute Polymer Engineering 4. Department of Veterinary, Rasht Branch, Islamic Azad University, Rasht, Iran
Abstract: Skin drug delivery systems with controlled release are suitable means for the local transfer of pharmaceutical compounds to the damaged and healthy layers of skin. Nanofbrous membrane prepares uniform moisture in the wound environment with less accumulation of fluid secretion due to its variable pore size. Electrospinning takes advantage of using herbal extracts in the form of electrospun nanofbrous mats as an alternative for skin grafs. In this study, afer preparing optimized fbrous mats of Poly lactic-co – glycolic acid (PLGA), characterization and identifcation of their chemical structure was carried out by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The drug release of the optimized electrospun nanofbrous mats and the kinetics of drug release were investigated in vitro. Then, wound dressing performance, antibacterial property, cell adhesion and biocompatibility of nanofbrous scaffolds prepared by Methyl Tiazolyl Tetrazolium (MTT) assays as well as important features of suitable wound dressing including porosity, Water Vapor Transmission Rate, and swelling percentage of nanofbrous mats were evaluated in vitro. Nanofbrous mats containing Hypericum perforatum extract without any bead with burst drug release kinetics followed Higuchi kinetic model with proper regression coefcient (PLGA-E10 = 0.8, PLGA-E 30 = 0.76). The results of the antibacterial activity of nanofbrous mats against Gram positive bacteria (S. aureus) as well as the results of the cell culture test and in vitro biodegradability tests on these mats showed good potential of composite scaffolds as antimicrobial coverage for wounds with Gram positive bacteria infectious agent.
Keywords: Drug Release, Kinetic, Electrospinning, Hypericum Perforatum, Poly Lactic-co–glycolic Acid
Application: Wound Dressing, Drug Delivery, Antibacterial Properties
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