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Title: Preparation of a reproducible long-acting formulation of risperidone-loaded PLGA microspheres using microfluidic method
Journal: Pharmaceutical development and technology
Author: 1. Elham Jafarifar, 2. Marziyeh Hajialyani, 2,4. Ali Fattahi, 3. Mona Akbari, Masoud Rahimi, 4. Yalda Shokoohinia
Year: 2016
Address: 1. Student research committee, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran 2. Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran 3. CFD research center, Chemical Engineering Department, Razi University, Kermanshah, Iran 4. Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract: The aim of the present study is to prepare risperidone loaded PLGA microspheres within microfluidic system and to achieve a formulation with uniform size, and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optimizing study was carried out at different processing parameters (e.g. PLGA and surfactant concentration and flow rates ratio of outer to inner phase). The computational fluid dynamic (CFD) modeling was performed, and loading and release study were carried out. CFD simulation indicates that increasing the flow rate of aqueous phase cause to decrease the droplet size while the change in size of microspheres did not follow a specific pattern in the experimental results. The most uniform microspheres and narrowest standard deviation (66.79 μm ± 3.32) were achieved using T-junction chip, 1% polyvinylalcohol, 1% PLGA and flow rates ratio of 20. The microfluidic-assisted microspheres were more uniform with narrower size distribution. The release of risperidone from microspheres produced by the microfluidic method was more reproducible and closer to zero-order kinetic model. The release profile of formulation with 2:1 drug to polymer ratio were the most favorable release, in which 41.85% release could be achieved during 24 days.
Keywords: microfluidics, monodisperse microspheres, risperidone, PLGA, The computational fluid dynamic, monotonic and reproducible release
Application: Drug Delivery
Product Model 1: Syringe Pump (SP1000)
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.1080/10837450.2016.1221426#="http://www.tandfonline.com" & "/doi/abs/10.1080/10837450.2016.1221426"#